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1

Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer

Vito Turk, Boris Turk, Gregor Gunčar, Dušan Turk, Janko Kos

Journal:

Advances in Enzyme Regulation

Année:

2002

Langue:

english

Fichier:

PDF, 269 KB

english, 2002

2

Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases

Marko Mihelič, Cory Teuscher, Vito Turk, Dušan Turk

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 226 KB

english, 2006

3

Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators

Turk, Boris, Turk, Dusan, Salvesen, Guy

Journal:

Current Pharmaceutical Design

Année:

2002

Langue:

english

Fichier:

PDF, 160 KB

english, 2002

4

Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets

Vasiljeva, Olga, Reinheckel, Thomas, Peters, Christoph, Turk, Dusan, Turk, Vito, Turk, Boris

Journal:

Current Pharmaceutical Design

Année:

2007

Langue:

english

Fichier:

PDF, 362 KB

english, 2007

5

Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds

Dr. Bojana Mirković, Dr. Miha Renko, Dr. Samo Turk, Izidor Sosič, Dr. Zala Jevnikar, Dr. Nataša Obermajer, Prof. Dr. Dušan Turk, Prof. Dr. Stanislav Gobec, Prof. Dr. Janko Kos

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 550 KB

english, 2011

6

The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis

Chelsee Hewitt, Derek McCormick, Gerry Linden, Dusan Turk, Igor Stern, Ian Wallace, Louise Southern, Liqun Zhang, Rebecca Howard, Pedro Bullon, Melanie Wong, Richard Widmer, Khaled Abdul Gaffar, Lama

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 287 KB

english, 2004

7

Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase

Ivica Klemenčič, Adriana K. Carmona, Maria Helena S. Cezari, Maria A. Juliano, Luiz Juliano, Gregor Gunčar, Dušan Turk, Igor Križaj, Vito Turk, Boris Turk

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 851 KB

english, 2000

8

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

Silvia Jordans, Saša Jenko-Kokalj, Nicole M Kühl, Sofia Tedelind, Wolfgang Sendt, Dieter Brömme, Dušan Turk, Klaudia Brix

Journal:

BMC Biochemistry

Année:

2009

Langue:

english

Fichier:

PDF, 2.47 MB

english, 2009

9

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

Wolfram Bode, Dusan Turk, Andrej Karshikov

Journal:

Protein Science

Année:

1992

Langue:

english

Fichier:

PDF, 11.93 MB

english, 1992

10

Different propensity to form amyloid fibrils by two homologous proteins—Human stefins A and B: Searching for an explanation

Saša Jenko, Miha Škarabot, Manca Kenig, Gregor Gunčar, Igor Muševič, Dušan Turk, Eva Žerovnik

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2004

Langue:

english

Fichier:

PDF, 333 KB

english, 2004

11

Folding and amyloid-fibril formation for a series of human stefins' chimeras: Any correlation?

Manca Kenig, Saša Jenko-Kokalj, Magda Tušek-Žnidarič, Maruša Pompe-Novak, Gregor Gunčar, Dušan Turk, Jonathan P. Waltho, Rosemarie A. Staniforth, Franc Avbelj, Eva Žerovnik

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2006

Langue:

english

Fichier:

PDF, 868 KB

english, 2006

12

The mechanism of amyloid-fibril formation by stefin B: Temperature and protein concentration dependence of the rates

Katja Škerget, Andrej Vilfan, Maruša Pompe-Novak, Vito Turk, Jonathan P. Waltho, Dušan Turk, Eva Žerovnik

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2009

Langue:

english

Fichier:

PDF, 378 KB

english, 2009

13

In vivoeffects of head-to-tail 3-alkylpiridinium polymers isolated from the marine spongeRaniera sarai

Matjaž Bunc, Kristina Sepčič, Tom Turk, Dušan šuput

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 434 KB

english, 2000

14

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

Jerica Rozman Pungerčar, Dejan Caglič, Mohammed Sajid, Marko Dolinar, Olga Vasiljeva, Urška Požgan, Dušan Turk, Matthew Bogyo, Vito Turk, Boris Turk

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 284 KB

english, 2009

15

A new phospholipase A2 isolated from the sea anemone Urticina crassicornis – its primary structure and phylogenetic classification

Andrej Razpotnik, Igor Križaj, Jernej Šribar, Dušan Kordiš, Peter Maček, Robert Frangež, William R. Kem, Tom Turk

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 535 KB

english, 2010

16

Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft

Miha Renko, Urška Požgan, Dušana Majera, Dušan Turk

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 572 KB

english, 2010

17

Mechanisms of amyloid fibril formation – focus on domain-swapping

Eva Žerovnik, Veronika Stoka, Andreja Mirtič, Gregor Gunčar, Jože Grdadolnik, Rosemary A. Staniforth, Dušan Turk, Vito Turk

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 481 KB

english, 2011

18

The p41 Fragment Story

Dusan Turk, Gregor Guncar, Vito Turk

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 546 KB

english, 1999

19

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S

Gunčar, Gregor, Pungerčič, Galina, Klemenčič, Ivica, Turk, Vito, Turk, Dušan

Journal:

The EMBO Journal

Année:

1999

Langue:

english

Fichier:

PDF, 719 KB

english, 1999

20

Primary structure of ammodytoxin C further reveals the toxic site of ammodytoxin

Igor Križaj, Dušan Turk, Anka Ritonja, Franc Gubenšek

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1989

Langue:

english

Fichier:

PDF, 241 KB

english, 1989

21

Essential role of Pro 74 in stefin B amyloid-fibril formation: Dual action of cyclophilin A on the process

Aida Smajlović, Selma Berbić, Cordelia Schiene-Fischer, Magda Tušek-Žnidarič, Ajda Taler, Saša Jenko-Kokalj, Dušan Turk, Eva Žerovnik

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 490 KB

english, 2009

22

Expression, purification and assembly of soluble multimeric MHC class II–invariant chain complexes

Dušana Majera, Katarina Črnigoj Kristan, Jacques Neefjes, Dušan Turk, Marko Mihelič

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2012

23

Inhibition of acetylcholinesterase by an alkylpyridinium polymer from the marine sponge, Reniera sarai

Kristina Sepčić, Véronique Marcel, Alain Klaebe, Tom Turk, Dušan Šuput, Didier Fournier

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1998

Langue:

english

Fichier:

PDF, 510 KB

english, 1998

24

Lysosomal cysteine proteases: more than scavengers

Boris Turk, Dušan Turk, Vito Turk

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

2000

Langue:

english

Fichier:

PDF, 971 KB

english, 2000

25

Crystal structure of cathepsin X: a flip–flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease

Gregor Gunčar, Ivica Klemenčič, Boris Turk, Vito Turk, Adriana Karaoglanovic-Carmona, Luiz Juliano, Dušan Turk

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 469 KB

english, 2000

26

Crystal structure of the apoptotic suppressor CrmA in its cleaved form

Martin Renatus, Qiao Zhou, Henning R Stennicke, Scott J Snipas, Dušan Turk, Laurie A Bankston, Robert C Liddington, Guy S Salvesen

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2000

27

Crystal Structure of the Soluble Form of Equinatoxin II, a Pore-Forming Toxin from the Sea Anemone Actinia equina

Alekos Athanasiadis, Gregor Anderluh, Peter Maček, Dušan Turk

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 461 KB

english, 2001

28

Crystal structure of porcine cathepsin H determined at 2.1 å resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function

Gregor Gunčar, Marjetka Podobnik, Jože Pungerčar, BorutŠtrukelj, Vito Turk, Dušan Turk

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 913 KB

english, 1998

29

Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes

Dušan Kordiš, Vito Turk

Journal:

BMC Evolutionary Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2009

30

Geometry of binding of the benzamidine- and arginine-based inhibitors Nα-(2-naphthyl-sulphonyl-glycyl)-dl-p-amidinophenylalanyl-piperidine (NAPAP) and (2R,4R)-4-methyl-1-[Nα-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulphonyl)-l-arginyl]-2-piperidine carboxylic acid (MQPA) to human α-thrombin : X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin

Wolfram BODE, Dušan TURK, Jörg STÜRZEBECHER

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 825 KB

english, 1990

31

4-Substituted Trinems as Broad Spectrum β-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity⊥

Plantan, Ivan, Selič, Lovro, Mesar, Tomaž, Anderluh, Petra Štefanič, Oblak, Marko, Preželj, Andrej, Hesse, Lars, Andrejašič, Miha, Vilar, Mateja, Turk, Dušan

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 264 KB

english, 2007

32

Inhibition Mechanism of Cathepsin L-Specific Inhibitors Based on the Crystal Structure of Papain–CLIK148 Complex

Hideaki Tsuge, Tomohiro Nishimura, Yukio Tada, Tetsuji Asao, Dusan Turk, Vito Turk, Nobuhiko Katunuma

Journal:

Biochemical and Biophysical Research Communications

Année:

1999

Langue:

english

Fichier:

PDF, 304 KB

english, 1999

33

Studies on the Lumazine Synthase/Riboflavin Synthase Complex ofBacillus subtilis: Crystal Structure Analysis of Reconstituted, Icosahedral β-subunit Capsids with Bound Substrate Analogue Inhibitor at 2.4 Å Resolution

Karl Ritsert, Robert Huber, Dusan Turk, Rudolf Ladenstein, Karen Schmidt-Bäse, Adelbert Bacher

Journal:

Journal of Molecular Biology

Année:

1995

Langue:

english

Fichier:

PDF, 4.77 MB

english, 1995

34

Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen

Marjetka Podobnik, Robert Kuhelj, Vito Turk, Dušan Turk

Journal:

Journal of Molecular Biology

Année:

1997

Langue:

english

Fichier:

PDF, 1.85 MB

english, 1997

35

Geometry of binding of the Nα-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin: X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes

Dušan Turk, Jörg Stürzebecher, Wolfram Bode

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 801 KB

english, 1991

36

Immunological studies of the toxic site in ammodytoxin A

Vladka Čurin-Šerbec, Djurdja Novak, Joža Babnik, Dušan Turk, Franc Gubenšek

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 539 KB

english, 1991

37

Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide

Dušan Turk, Marjeta Podobnik, Robert Kuhelj, Marko Dolinar, Vito Turk

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 456 KB

english, 1996

38

Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2·0Åresolution

Maria Joa˜o Roma˜o, Dusan Turk, Franz-Xaver Gomis-Rüth, Robert Huber, Günther Schumacher, Hans Möllering, Lorenz Rüssmann

Journal:

Journal of Molecular Biology

Année:

1992

Langue:

english

Fichier:

PDF, 2.10 MB

english, 1992

39

Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA: A starting point for improving antithrombotics

Hans Brandstetter, Dusan Turk, H. Wolfgang Hoeffken, Doris Grosse, Jörg Stürzebecher, Philip D. Martin, Brian F.P. Edwards, Wolfram Bode

Journal:

Journal of Molecular Biology

Année:

1992

Langue:

english

Fichier:

PDF, 4.38 MB

english, 1992

40

Inhibition of acetylcholinesterase by a pseudozoanthoxanthin-like compound isolated from the zoanthid Parazoanthus axinellae (O. Schmidt)

Tom Turk, Peter Maček, Dušan Šuput

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 750 KB

english, 1995

41

Cysteine cathepsins: From structure, function and regulation to new frontiers

Vito Turk, Veronika Stoka, Olga Vasiljeva, Miha Renko, Tao Sun, Boris Turk, Dušan Turk

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2012

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2012

42

Amyloid fibril formation by human stefins: Structure, mechanism & putative functions

Eva Žerovnik, Rosemary A. Staniforth, Dušan Turk

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2010

43

Essential Role of Proline Isomerization in Stefin B Tetramer Formation

Saša Jenko Kokalj, Gregor Gunčar, Igor Štern, Gareth Morgan, Sabina Rabzelj, Manca Kenig, Rosemary A. Staniforth, Jonathan P. Waltho, Eva Žerovnik, Dušan Turk

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2007

44

Crystal Structure of Stefin A in Complex with Cathepsin H: N-terminal Residues of Inhibitors can Adapt to the Active Sites of Endo- and Exopeptidases

Saša Jenko, Iztok Dolenc, Gregor Gunčar, Andreja Doberšek, Marjetka Podobnik, Dušan Turk

Journal:

Journal of Molecular Biology

Année:

2003

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2003

45

Modulation of Contact Order Effects in the Two-State Folding of Stefins A and B

Jelinska, Clare, Davis, Peter J., Kenig, Manca, Žerovnik, Eva, Kokalj, Saša Jenko, Gunčar, Gregor, Turk, Dušan, Turk, Vito, Clarke, David T., Waltho, Jonathan P., Staniforth, Rosemary A.

Journal:

Biophysical Journal

Année:

2011

Langue:

english

Fichier:

PDF, 396 KB

english, 2011

46

Acetylcholinesterase inhibition in CNS and in peripheral nerves by pax isolated from the coral parazoanthus axinellae

Jerneja Strupi Suput, Tom Turk, Dusan Suput

Journal:

Pathophysiology

Année:

1998

Langue:

english

Fichier:

PDF, 146 KB

english, 1998

47

Effects of Equinatoxins in Vivo : Possible Role of Degranulation of Thrombocytes and Granulocytes

MATJAŽ BUNC, ROBERT FRANGEŽ, IRENA HORVAT, TOM TURK, DUŠAN ŠUPUT

Journal:

Annals of the New York Academy of Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 303 KB

english, 1994

48

Structure-Based Discovery of Substituted 4,5′-Bithiazoles as Novel DNA Gyrase Inhibitors

Brvar, Matjaž, Perdih, Andrej, Renko, Miha, Anderluh, Gregor, Turk, Dušan, Solmajer, Tom

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 4.10 MB

english, 2012

49

Human Cathepsin B Is a Metastable Enzyme Stabilized by Specific Ionic Interactions Associated with the Active Site

Turk, Boris, Dolenc, Iztok, Zerovnik, Eva, Turk, Dusan, Gubensek, Franc, Turk, Vito

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 813 KB

english, 1994

50

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C

Poreba, Marcin, Mihelic, Marko, Krai, Priscilla, Rajkovic, Jelena, Krezel, Artur, Pawelczak, Malgorzata, Klemba, Michael, Turk, Dusan, Turk, Boris, Latajka, Rafal, Drag, Marcin

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 896 KB

english, 2014